The main centre of the Tuscan Valtiberina, it boasts a valuable historical centre, closed by a wall bounded by gunboats and an imposing Medici Fortress (1350). The main square (Piazza Torre di Berta) is overlooked by Palazzo Pichi (16th century) and Palazzo Giovagnoli (13th century); a short distance away is the Duomo, a Romanesque-Gothic Cathedral with a large rose window. To the left of the Cathedral there are the Palazzo delle Laudi (1595), the Palazzo Pretorio (14th century, ancient seat of the Florentine government) and the Municipal Picture Gallery. The latter houses various works by Piero della Francesca, including the famous Resurrection. In the historical centre of Sansepolcro takes place every second Sunday of September the Palio della Balestra, an ancient and suggestive folklore event in costume. The town is the seat of important textile and food factories (the Buitoni brand, known all over the world, was born in Sansepolcro).